Cologne, a 2,000-year-old city spanning the Rhine River in western Germany, is the region’s cultural hub. A landmark of High Gothic architecture set amid reconstructed old town, the twin-spired Cologne Cathedral is also known for its gilded medieval reliquary and sweeping river views. The adjacent Museum Ludwig showcases 20th-century art, including many masterpieces by Picasso, and the Romano-Germanic Museum houses Roman antiquities. ― Google

Rüdesheim am Rhein is a town in the Rhine Valley, Germany. It’s known for winemaking, especially of Riesling wines. In the center, Drosselgasse is a lane lined with shops, taverns and restaurants. Nearby, Siegfried’s Mechanical Music Cabinet is a museum of automated musical instruments. Medieval Brömserburg Castle is home to the Rheingau Wine Museum, exhibiting wine paraphernalia from ancient times to the present. ― Google

Würzburg is a city in Germany’s Bavaria region. It’s known for lavish baroque and rococo architecture, particularly the 18th-century Residenz palace, with ornate rooms, a huge fresco by Venetian artist Tiepolo and an elaborate staircase. Home to numerous wine bars, cellars and wineries, Würzburg is the center of the Franconian wine country, with its distinctive bocksbeutel (bottles with flattened round shapes). ― Google

Bamberg is a town in northern Bavaria, Germany, laid out over 7 hills where the Regnitz and Main rivers meet. Its old town preserves structures from the 11th to 19th centuries including the muraled Altes Rathaus (town hall), which occupies an island in the Regnitz reached by arched bridges. The Romanesque Bamberg Cathedral, begun in the 11th century, features 4 towers and numerous stone carvings. ― Google

Nuremberg is the second-largest city of the German state of Bavaria after its capital Munich, and its 541,000 inhabitants make it the 14th-largest city in Germany. Wikipedia

Passau, a German city on the Austrian border, lies at the confluence of the Danube, Inn and Ilz rivers. Known as the Three Rivers City, it’s overlooked by the Veste Oberhaus, a 13th-century hilltop fortress housing a city museum and observation tower. The old town below is known for its baroque architecture, including St. Stephen’s Cathedral, featuring distinctive onion-domed towers and an organ with 17,974 pipes. ― Google